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SEC Filings
Date Filed Filing Description Size View
Jul 3, 2017 4 thero, john f 156.0 KB HTML PDF XLS
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Jul 3, 2017 4 ketchum, steven b 153.6 KB HTML PDF XLS
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Jul 3, 2017 4 kennedy, joseph t 159.9 KB HTML PDF XLS
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Jul 3, 2017 4 kalb, michael wayne 153.9 KB HTML PDF XLS
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May 19, 2017 8-K current report 127.8 KB HTML PDF XLS
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May 17, 2017 4 stack, david m 154.7 KB HTML PDF XLS
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May 17, 2017 4 van, heek g jan 173.2 KB HTML PDF XLS
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May 17, 2017 4 peterson, kristine 154.4 KB HTML PDF XLS
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May 17, 2017 4 zakrzewski, joseph s 155.2 KB HTML PDF XLS
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May 17, 2017 4 ekman, lars 154.8 KB HTML PDF XLS
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May 17, 2017 4 o'sullivan, patrick j 154.5 KB HTML PDF XLS
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May 3, 2017 10-Q quarterly report 611.0 KB HTML PDF XLS XBRL Add to Briefcase
May 3, 2017 8-K current report 240.6 KB HTML PDF XLS
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Apr 21, 2017 DEF 14A definitive proxy statement 579.4 KB HTML PDF XLS
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Apr 3, 2017 4 kennedy, joseph t 156.3 KB HTML PDF XLS
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Apr 3, 2017 4 thero, john f 155.1 KB HTML PDF XLS
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Mar 27, 2017 8-K current report 123.0 KB HTML PDF XLS
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Mar 1, 2017 S-3ASR automatic shelf registration statement of securities of well-known seasoned issuers 1.1 MB HTML PDF XLS
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Mar 1, 2017 S-3ASR automatic shelf registration statement of securities of well-known seasoned issuers 371.0 KB HTML PDF XLS
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Mar 1, 2017 10-K annual report 1.1 MB HTML PDF XLS XBRL Add to Briefcase
Feb 28, 2017 8-K current report 244.9 KB HTML PDF XLS
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Feb 2, 2017 4 thero, john f 157.4 KB HTML PDF XLS
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Feb 2, 2017 4 ketchum, steven b 158.1 KB HTML PDF XLS
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Feb 2, 2017 4 kennedy, joseph t 157.4 KB HTML PDF XLS
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Feb 2, 2017 4 kalb, michael wayne 152.0 KB HTML PDF XLS
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Jan 25, 2017 8-K current report 587.0 KB HTML PDF XLS
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Jan 20, 2017 8-K current report 202.8 KB HTML PDF XLS
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Jan 5, 2017 8-K current report 194.7 KB HTML PDF XLS
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Jan 3, 2017 4 kennedy, joseph t 156.3 KB HTML PDF XLS
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Jan 3, 2017 4 thero, john f 155.0 KB HTML PDF XLS
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Dec 16, 2016 8-K current report 147.0 KB HTML PDF XLS
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Nov 10, 2016 4 kennedy, joseph t 153.6 KB HTML PDF XLS
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Nov 3, 2016 10-Q quarterly report 638.5 KB HTML PDF XLS XBRL Add to Briefcase
Nov 3, 2016 8-K current report 248.0 KB HTML PDF XLS
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Sep 30, 2016 4 kennedy, joseph t 156.0 KB HTML PDF XLS
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Sep 30, 2016 4 thero, john f 154.7 KB HTML PDF XLS
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Sep 23, 2016 8-K current report 111.5 KB HTML PDF XLS
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Sep 14, 2016 8-K current report 162.1 KB HTML PDF XLS
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Aug 26, 2016 8-K current report 147.0 KB HTML PDF XLS
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Aug 15, 2016 8-K current report 155.2 KB HTML PDF XLS
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Aug 12, 2016 F-6EF form f-6ef 543.7 KB HTML PDF XLS
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Aug 12, 2016 8-K current report 324.9 KB HTML PDF XLS
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Aug 12, 2016 424B5 prospectus filed pursuant to rule 424 590.9 KB HTML PDF XLS
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Aug 10, 2016 424B5 prospectus filed pursuant to rule 424 591.1 KB HTML PDF XLS
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Aug 4, 2016 10-Q quarterly report 636.8 KB HTML PDF XLS XBRL Add to Briefcase
Aug 4, 2016 8-K current report 267.4 KB HTML PDF XLS
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Jul 14, 2016 8-K current report 109.1 KB HTML PDF XLS
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Jul 13, 2016 4 healy, james 174.2 KB HTML PDF XLS
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Jul 13, 2016 4 o'sullivan, patrick j 177.3 KB HTML PDF XLS
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Jul 13, 2016 4 peterson, kristine 175.0 KB HTML PDF XLS
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Jul 13, 2016 4 stack, david m 175.9 KB HTML PDF XLS
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Jul 13, 2016 4 van, heek g jan 155.0 KB HTML PDF XLS
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Jul 13, 2016 4 zakrzewski, joseph s 177.7 KB HTML PDF XLS
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Jul 13, 2016 4 ekman, lars 174.8 KB HTML PDF XLS
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Jul 5, 2016 4 kalb, michael wayne 153.0 KB HTML PDF XLS
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Jul 5, 2016 4 thero, john f 174.4 KB HTML PDF XLS
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Jul 5, 2016 4 kennedy, joseph t 177.4 KB HTML PDF XLS
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Jul 5, 2016 3 kalb michael wayne 185.9 KB HTML PDF XLS
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Jun 30, 2016 8-K current report 224.9 KB HTML PDF XLS
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Jun 8, 2016 8-K current report 104.1 KB HTML PDF XLS
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Jun 1, 2016 8-K current report 120.5 KB HTML PDF XLS
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May 5, 2016 10-Q quarterly report 585.4 KB HTML PDF XLS XBRL Add to Briefcase
May 5, 2016 8-K current report 200.0 KB HTML PDF XLS
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Apr 29, 2016 DEF 14A definitive proxy statement 478.9 KB HTML PDF XLS
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Apr 1, 2016 4 kennedy, joseph t 156.0 KB HTML PDF XLS
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Apr 1, 2016 4 thero, john f 154.7 KB HTML PDF XLS
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Mar 9, 2016 8-K current report 125.6 KB HTML PDF XLS
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Feb 25, 2016 10-K annual report 939.0 KB HTML PDF XLS XBRL Add to Briefcase
Feb 25, 2016 8-K current report 231.2 KB HTML PDF XLS
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Feb 12, 2016 SC 13G statement of beneficial ownership 114.5 KB HTML PDF XLS
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Feb 3, 2016 4 thero, john f 150.0 KB HTML PDF XLS
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Feb 2, 2016 4 thero, john f 157.0 KB HTML PDF XLS
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Feb 2, 2016 4 ketchum, steven b 157.5 KB HTML PDF XLS
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Feb 2, 2016 4 kennedy, joseph t 157.0 KB HTML PDF XLS
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Feb 2, 2016 4 farrell, michael james 157.7 KB HTML PDF XLS
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Jan 25, 2016 8-K current report 104.3 KB HTML PDF XLS
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Jan 11, 2016 8-K current report 197.9 KB HTML PDF XLS
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Jan 4, 2016 4 thero, john f 153.5 KB HTML PDF XLS
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Jan 4, 2016 4 kennedy, joseph t 156.4 KB HTML PDF XLS
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Dec 1, 2015 8-K current report 126.7 KB HTML PDF XLS
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Nov 20, 2015 8-K current report 431.7 KB HTML PDF XLS
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Nov 4, 2015 10-Q quarterly report 596.4 KB HTML PDF XLS XBRL Add to Briefcase
Nov 4, 2015 8-K current report 231.3 KB HTML PDF XLS
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Oct 6, 2015 4 kennedy, joseph t 155.6 KB HTML PDF XLS
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Oct 2, 2015 4 thero, john f 153.6 KB HTML PDF XLS
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Oct 2, 2015 4 kennedy, joseph t 154.7 KB HTML PDF XLS
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Aug 11, 2015 4 thero, john f 25.9 KB HTML PDF XLS
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Aug 7, 2015 8-K current report 28.2 KB HTML PDF XLS
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Aug 6, 2015 10-Q quarterly report 471.3 KB HTML PDF XLS XBRL Add to Briefcase
Aug 6, 2015 8-K current report 93.9 KB HTML PDF XLS
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Jul 24, 2015 S-8 registration statement 81.8 KB HTML PDF XLS
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Jul 24, 2015 S-3 registration statement 203.5 KB HTML PDF XLS
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Jul 14, 2015 4 healy, james 26.0 KB HTML PDF XLS
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Jul 10, 2015 8-K current report 44.1 KB HTML PDF XLS
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Jul 8, 2015 4 peterson, kristine 29.7 KB HTML PDF XLS
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Jul 8, 2015 4 healy, james 29.7 KB HTML PDF XLS
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Jul 8, 2015 4 van, heek g jan 29.7 KB HTML PDF XLS
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Jul 8, 2015 4 zakrzewski, joseph s 29.7 KB HTML PDF XLS
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Jul 8, 2015 4 stack, david m 29.7 KB HTML PDF XLS
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Jul 8, 2015 4 o'sullivan, patrick j 29.8 KB HTML PDF XLS
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Jul 8, 2015 4 ekman, lars 29.6 KB HTML PDF XLS
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Jul 8, 2015 4 thero, john f 26.6 KB HTML PDF XLS
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Jul 8, 2015 4 kennedy, joseph t 26.6 KB HTML PDF XLS
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Jul 8, 2015 4 ketchum, steven b 25.2 KB HTML PDF XLS
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Jul 8, 2015 4 farrell, michael james 25.1 KB HTML PDF XLS
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Jul 1, 2015 CT ORDER confidential treatment order 9.1 KB HTML PDF
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May 29, 2015 8-K current report 25.4 KB HTML PDF XLS
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May 8, 2015 10-Q quarterly report 1.4 MB HTML PDF XLS XBRL Add to Briefcase
May 8, 2015 8-K current report 109.3 KB HTML PDF XLS
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May 7, 2015 8-K current report 41.0 KB HTML PDF XLS
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Apr 28, 2015 8-K current report 37.0 KB HTML PDF XLS
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Apr 24, 2015 S-3/A registration statement 130.2 KB HTML PDF XLS
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Apr 24, 2015 DEF 14A definitive proxy statement 548.7 KB HTML PDF XLS
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Apr 22, 2015 F-6 other 716.6 KB HTML PDF XLS
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Apr 9, 2015 S-3 registration statement 378.2 KB HTML PDF XLS
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Apr 3, 2015 PRE 14A preliminary proxy statement 529.9 KB HTML PDF XLS
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Mar 30, 2015 8-K current report 828.5 KB HTML PDF XLS
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Mar 11, 2015 8-K current report 426.7 KB HTML PDF XLS
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Mar 3, 2015 10-K annual report 1.3 MB HTML PDF XLS XBRL Add to Briefcase
Mar 3, 2015 8-K current report 129.2 KB HTML PDF XLS
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Feb 9, 2015 SC 13G/A amended statement of beneficial ownership 45.8 KB HTML PDF XLS
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Feb 3, 2015 8-K current report 26.3 KB HTML PDF XLS
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Feb 2, 2015 4 farrell, michael james 28.5 KB HTML PDF XLS
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Feb 2, 2015 4 ketchum, steven b 28.5 KB HTML PDF XLS
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Feb 2, 2015 4 kennedy, joseph t 28.5 KB HTML PDF XLS
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Feb 2, 2015 4 thero, john f 28.5 KB HTML PDF XLS
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Jan 12, 2015 8-K current report 25.1 KB HTML PDF XLS
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Nov 19, 2014 SC 13G statement of beneficial ownership 46.0 KB HTML PDF XLS
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Nov 14, 2014 8-K current report 27.1 KB HTML PDF XLS
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Nov 12, 2014 4 farrell, michael james 22.3 KB HTML PDF XLS
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Nov 12, 2014 4 thero, john f 25.3 KB HTML PDF XLS
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Nov 6, 2014 10-Q quarterly report 783.2 KB HTML PDF XLS XBRL Add to Briefcase
Nov 6, 2014 8-K current report 119.5 KB HTML PDF XLS
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Oct 16, 2014 8-K current report 38.2 KB HTML PDF XLS
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Sep 16, 2014 8-K current report 34.7 KB HTML PDF XLS
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Aug 15, 2014 DEL AM miscellaneous 18.4 KB HTML PDF
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Aug 7, 2014 10-Q quarterly report 828.4 KB HTML PDF XLS XBRL Add to Briefcase
Aug 7, 2014 8-K current report 119.7 KB HTML PDF XLS
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Aug 7, 2014 S-3 registration statement 1.9 MB HTML PDF XLS
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Jul 10, 2014 8-K current report 31.0 KB HTML PDF XLS
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Jun 26, 2014 CT ORDER confidential treatment order 7.1 KB HTML PDF
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May 21, 2014 8-K current report 747.5 KB HTML PDF XLS
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May 15, 2014 8-K current report 60.4 KB HTML PDF XLS
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May 9, 2014 10-Q quarterly report 1.1 MB HTML PDF XLS XBRL Add to Briefcase
May 9, 2014 8-K current report 108.9 KB HTML PDF XLS
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Apr 30, 2014 DEF 14A definitive proxy statement 406.6 KB HTML PDF XLS
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Mar 31, 2014 8-K current report 73.1 KB HTML PDF XLS
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Mar 14, 2014 8-K current report 39.5 KB HTML PDF XLS
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Mar 13, 2014 4 stack, david m 26.2 KB HTML PDF XLS
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Mar 13, 2014 4 peterson, kristine 26.3 KB HTML PDF XLS
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Mar 13, 2014 4 healy, james 26.4 KB HTML PDF XLS
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Mar 13, 2014 4 van, heek g jan 26.3 KB HTML PDF XLS
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Mar 13, 2014 4 ekman, lars 28.5 KB HTML PDF XLS
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Mar 13, 2014 4 o'sullivan, patrick j 26.4 KB HTML PDF XLS
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Mar 13, 2014 4 zakrzewski, joseph s 26.3 KB HTML PDF XLS
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Mar 6, 2014 8-K current report 31.6 KB HTML PDF XLS
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Mar 4, 2014 8-K current report 26.8 KB HTML PDF XLS
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Feb 27, 2014 10-K annual report 1.2 MB HTML PDF XLS XBRL Add to Briefcase
Feb 27, 2014 8-K current report 117.8 KB HTML PDF XLS
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Feb 21, 2014 8-K current report 26.9 KB HTML PDF XLS
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Jan 24, 2014 8-K current report 48.1 KB HTML PDF XLS
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Jan 10, 2014 8-K current report 109.6 KB HTML PDF XLS
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Jan 10, 2014 4 farrell, michael james 27.9 KB HTML PDF XLS
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Jan 10, 2014 4 ketchum, steven b 27.9 KB HTML PDF XLS
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Jan 10, 2014 4 thero, john f 27.8 KB HTML PDF XLS
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Jan 10, 2014 4 kennedy, joseph t 28.0 KB HTML PDF XLS
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Jan 9, 2014 3 farrell michael james 22.4 KB HTML PDF XLS
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Dec 20, 2013 8-K current report 26.7 KB HTML PDF XLS
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Dec 16, 2013 8-K current report 24.9 KB HTML PDF XLS
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Dec 2, 2013 8-K current report 26.8 KB HTML PDF XLS
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Nov 22, 2013 8-K current report 27.4 KB HTML PDF XLS
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Nov 20, 2013 4 ekman, lars 22.3 KB HTML PDF XLS
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Nov 20, 2013 4 thero, john f 24.8 KB HTML PDF XLS
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Nov 18, 2013 4 zakrzewski, joseph s 25.9 KB HTML PDF XLS
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Nov 7, 2013 10-Q quarterly report 712.6 KB HTML PDF XLS XBRL Add to Briefcase
Nov 7, 2013 8-K current report 161.1 KB HTML PDF XLS
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Oct 29, 2013 8-K current report 28.6 KB HTML PDF XLS
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Oct 22, 2013 8-K current report 25.6 KB HTML PDF XLS
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Oct 16, 2013 8-K current report 23.9 KB HTML PDF XLS
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Aug 23, 2013 SC 13D/A amended general statement of beneficial ownership 120.6 KB HTML PDF XLS
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Aug 8, 2013 10-Q quarterly report 872.7 KB HTML PDF XLS XBRL Add to Briefcase
Aug 8, 2013 8-K current report 156.1 KB HTML PDF XLS
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Jul 26, 2013 4 zakrzewski, joseph s 27.5 KB HTML PDF XLS
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Jul 26, 2013 4 kennedy, joseph t 27.3 KB HTML PDF XLS
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Jul 26, 2013 4 thero, john f 27.4 KB HTML PDF XLS
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Jul 22, 2013 SC 13D/A amended general statement of beneficial ownership 117.4 KB HTML PDF XLS
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Jul 12, 2013 8-K current report 39.0 KB HTML PDF XLS
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Jul 11, 2013 4 healy, james 26.4 KB HTML PDF XLS
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Jul 11, 2013 4 stack, david m 26.4 KB HTML PDF XLS
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Jul 11, 2013 4 van, heek g jan 27.4 KB HTML PDF XLS
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Jul 11, 2013 4 peterson, kristine 26.4 KB HTML PDF XLS
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Jul 11, 2013 4 ekman, lars 26.4 KB HTML PDF XLS
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Jul 11, 2013 4 o'sullivan, patrick j 26.5 KB HTML PDF XLS
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Jul 10, 2013 8-K current report 361.5 KB HTML PDF XLS
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Jul 10, 2013 424B5 prospectus filed pursuant to rule 424 835.0 KB HTML PDF XLS
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Jul 8, 2013 424B5 prospectus filed pursuant to rule 424 830.5 KB HTML PDF XLS
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Jul 8, 2013 8-K current report 33.9 KB HTML PDF XLS
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Jun 25, 2013 4 zakrzewski, joseph s 26.8 KB HTML PDF XLS
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Jun 21, 2013 4 zakrzewski, joseph s 26.8 KB HTML PDF XLS
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Jun 19, 2013 8-K current report 50.9 KB HTML PDF XLS
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May 29, 2013 4 thero, john f 26.2 KB HTML PDF XLS
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May 9, 2013 10-Q quarterly report 1.1 MB HTML PDF XLS XBRL Add to Briefcase
May 9, 2013 8-K current report 161.5 KB HTML PDF XLS
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Apr 30, 2013 8-K current report 22.6 KB HTML PDF XLS
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Apr 25, 2013 4 zakrzewski, joseph s 26.8 KB HTML PDF XLS
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Apr 23, 2013 8-K current report 23.7 KB HTML PDF XLS
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Apr 23, 2013 DEF 14A definitive proxy statement 851.0 KB HTML PDF XLS
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Apr 18, 2013 8-K current report 22.5 KB HTML PDF XLS
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Apr 17, 2013 CT ORDER confidential treatment order 6.2 KB HTML PDF
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Apr 15, 2013 4 van, heek g jan 24.3 KB HTML PDF XLS
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Mar 28, 2013 8-K current report 24.2 KB HTML PDF XLS
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Mar 25, 2013 PRE 14A preliminary proxy statement 853.3 KB HTML PDF XLS
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Feb 28, 2013 10-K annual report 1.4 MB HTML PDF XLS XBRL Add to Briefcase
Feb 28, 2013 8-K current report 108.6 KB HTML PDF XLS
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Feb 27, 2013 8-K current report 26.6 KB HTML PDF XLS
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Feb 14, 2013 SC 13G/A amended statement of beneficial ownership 74.9 KB HTML PDF XLS
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Feb 14, 2013 SC 13G/A amended statement of beneficial ownership 31.9 KB HTML PDF XLS
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Feb 13, 2013 SC 13G/A amended statement of beneficial ownership 78.3 KB HTML PDF XLS
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Jan 30, 2013 4 thero, john f 26.1 KB HTML PDF XLS
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Jan 25, 2013 8-K current report 28.1 KB HTML PDF XLS
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Jan 14, 2013 4 van, heek g jan 24.3 KB HTML PDF XLS
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Jan 2, 2013 4 zakrzewski, joseph s 25.6 KB HTML PDF XLS
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Jan 2, 2013 4 thero, john f 25.5 KB HTML PDF XLS
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Jan 2, 2013 4 ketchum, steven b 25.3 KB HTML PDF XLS
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Jan 2, 2013 4 kennedy, joseph t 25.3 KB HTML PDF XLS
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Dec 19, 2012 8-K current report 22.7 KB HTML PDF XLS
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Dec 12, 2012 8-K current report 62.2 KB HTML PDF XLS
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Dec 12, 2012 4 stack, david m 24.0 KB HTML PDF XLS
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Dec 12, 2012 3 stack david m 23.1 KB HTML PDF XLS
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Nov 29, 2012 8-K current report 25.8 KB HTML PDF XLS
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Nov 23, 2012 CT ORDER confidential treatment order 8.9 KB HTML PDF
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Nov 8, 2012 10-Q quarterly report 537.0 KB HTML PDF XLS XBRL Add to Briefcase
Nov 8, 2012 8-K current report 97.6 KB HTML PDF XLS
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Oct 12, 2012 4 van, heek g jan 24.2 KB HTML PDF XLS
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Oct 10, 2012 8-K current report 31.0 KB HTML PDF XLS
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Oct 3, 2012 4 zakrzewski, joseph s 28.6 KB HTML PDF XLS
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Sep 24, 2012 4 thero, john f 25.4 KB HTML PDF XLS
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Sep 14, 2012 CT ORDER confidential treatment order 7.1 KB HTML PDF
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Sep 11, 2012 4 thero, john f 25.4 KB HTML PDF XLS
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Sep 10, 2012 8-K current report 28.0 KB HTML PDF XLS
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Sep 5, 2012 4 healy, james 27.2 KB HTML PDF XLS
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Sep 5, 2012 4 gordon, carl l 28.3 KB HTML PDF XLS
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Sep 5, 2012 4 orbimed, advisors llc 30.3 KB HTML PDF XLS
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Aug 17, 2012 8-K current report 26.2 KB HTML PDF XLS
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Aug 15, 2012 4 healy, james 26.6 KB HTML PDF XLS
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Aug 8, 2012 S-8 registration statement 112.6 KB HTML PDF XLS
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Aug 8, 2012 10-Q quarterly report 625.3 KB HTML PDF XLS XBRL Add to Briefcase
Aug 8, 2012 8-K current report 95.0 KB HTML PDF XLS
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Aug 6, 2012 CT ORDER confidential treatment order 7.1 KB HTML PDF
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Jul 30, 2012 4 gordon, carl l 28.3 KB HTML PDF XLS
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Jul 30, 2012 4 orbimed, advisors llc 30.3 KB HTML PDF XLS
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Jul 30, 2012 4 zakrzewski, joseph s 30.5 KB HTML PDF XLS
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Jul 30, 2012 4 thero, john f 32.1 KB HTML PDF XLS
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Jul 30, 2012 4 kennedy, joseph t 28.8 KB HTML PDF XLS
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Jul 30, 2012 4 huff, paul 28.7 KB HTML PDF XLS
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Jul 30, 2012 4 sedlack, stuart d 28.7 KB HTML PDF XLS
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Jul 30, 2012 SC 13D/A amended general statement of beneficial ownership 125.9 KB HTML PDF XLS
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Jul 27, 2012 8-K current report 74.1 KB HTML PDF XLS
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Jul 19, 2012 8-K current report 24.0 KB HTML PDF XLS
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Jul 13, 2012 4 healy, james 24.8 KB HTML PDF XLS
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Jul 12, 2012 4 anderson, joseph 27.1 KB HTML PDF XLS
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Jul 12, 2012 4 peterson, kristine 24.8 KB HTML PDF XLS
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Jul 12, 2012 4 o'sullivan, patrick j 24.9 KB HTML PDF XLS
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Jul 12, 2012 4 ekman, lars 24.8 KB HTML PDF XLS
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Jul 12, 2012 4 van, heek g jan 25.8 KB HTML PDF XLS
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Jul 12, 2012 4 gordon, carl l 24.8 KB HTML PDF XLS
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Jul 12, 2012 8-K current report 35.7 KB HTML PDF XLS
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Jul 6, 2012 8-K current report 22.7 KB HTML PDF XLS
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Jun 27, 2012 4 huff, paul 28.2 KB HTML PDF XLS
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Jun 19, 2012 4 gordon, carl l 28.1 KB HTML PDF XLS
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Jun 19, 2012 4 orbimed, advisors llc 30.0 KB HTML PDF XLS
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Jun 19, 2012 4 huff, paul 28.1 KB HTML PDF XLS
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Jun 8, 2012 4 huff, paul 28.1 KB HTML PDF XLS
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Jun 6, 2012 SC 13D/A amended general statement of beneficial ownership 216.2 KB HTML PDF XLS
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May 31, 2012 4 zakrzewski, joseph s 27.4 KB HTML PDF XLS
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May 8, 2012 10-Q quarterly report 297.3 KB HTML PDF XLS XBRL Add to Briefcase
May 8, 2012 8-K current report 93.3 KB HTML PDF XLS
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Apr 27, 2012 DEF 14A definitive proxy statement 584.8 KB HTML PDF XLS
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Apr 27, 2012 SC 13D/A amended general statement of beneficial ownership 120.3 KB HTML PDF XLS
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Apr 26, 2012 4/A abingworth llp 27.1 KB HTML PDF XLS
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Apr 26, 2012 424B3 prospectus filed pursuant to rule 424 25.1 KB HTML PDF XLS
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Apr 19, 2012 4 abingworth, llp 27.0 KB HTML PDF XLS
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Apr 16, 2012 SC 13D/A amended general statement of beneficial ownership 117.8 KB HTML PDF XLS
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Apr 12, 2012 4 van, heek g jan 24.3 KB HTML PDF XLS
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Apr 11, 2012 4 thero, john f 26.7 KB HTML PDF XLS
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Apr 9, 2012 424B3 prospectus filed pursuant to rule 424 25.7 KB HTML PDF XLS
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Apr 6, 2012 4 healy, james 25.3 KB HTML PDF XLS
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Apr 5, 2012 4 abingworth, llp 26.0 KB HTML PDF XLS
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Apr 4, 2012 4 healy, james 25.9 KB HTML PDF XLS
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Mar 30, 2012 4 healy, james 25.4 KB HTML PDF XLS
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Mar 27, 2012 4 zakrzewski, joseph s 27.1 KB HTML PDF XLS
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Mar 20, 2012 8-K current report 19.6 KB HTML PDF XLS
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Mar 19, 2012 CT ORDER confidential treatment order 7.2 KB HTML PDF
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Mar 16, 2012 S-8 registration statement 204.1 KB HTML PDF XLS
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Mar 5, 2012 4 ketchum, steven b 24.9 KB HTML PDF XLS
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Mar 2, 2012 8-K current report 28.9 KB HTML PDF XLS
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Feb 29, 2012 8-K current report 122.8 KB HTML PDF XLS
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Feb 29, 2012 10-K annual report 1.7 MB HTML PDF XLS XBRL Add to Briefcase
Feb 21, 2012 3 ketchum steven b 23.3 KB HTML PDF XLS
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Feb 16, 2012 8-K current report 142.0 KB HTML PDF XLS
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Feb 14, 2012 SC 13G/A amended statement of beneficial ownership 28.4 KB HTML PDF XLS
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Feb 14, 2012 SC 13G/A amended statement of beneficial ownership 83.8 KB HTML PDF XLS
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Feb 3, 2012 4 soni, paresh 24.6 KB HTML PDF XLS
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Feb 3, 2012 4 sedlack, stuart d 24.6 KB HTML PDF XLS
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Feb 1, 2012 SC 13D/A amended general statement of beneficial ownership 65.0 KB HTML PDF XLS
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Jan 31, 2012 4 healy, james 26.1 KB HTML PDF XLS
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Dec 12, 2011 SC 13G/A amended statement of beneficial ownership 28.4 KB HTML PDF XLS
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Nov 22, 2011 CT ORDER confidential treatment order 7.1 KB HTML PDF
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Nov 8, 2011 10-Q quarterly report 400.3 KB HTML PDF XLS XBRL Add to Briefcase
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Oct 20, 2011 SC 13D/A amended general statement of beneficial ownership 290.9 KB HTML PDF XLS
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Sep 30, 2011 8-K current report 24.0 KB HTML PDF XLS
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Sep 16, 2011 S-8 registration statement 237.1 KB HTML PDF XLS
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May 10, 2011 10-Q quarterly report 286.0 KB HTML PDF XLS
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May 9, 2011 3 abingworth llp 27.8 KB HTML PDF XLS
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May 6, 2011 SC 13D/A amended general statement of beneficial ownership 92.5 KB HTML PDF XLS
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May 3, 2011 4 orbimed, advisors llc 30.9 KB HTML PDF XLS
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May 2, 2011 DEF 14A definitive proxy statement 652.0 KB HTML PDF XLS
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Apr 28, 2011 SC 13D/A amended general statement of beneficial ownership 67.3 KB HTML PDF XLS
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Apr 21, 2011 424B3 prospectus filed pursuant to rule 424 25.0 KB HTML PDF
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Apr 18, 2011 8-K current report 61.3 KB HTML PDF XLS
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Mar 29, 2011 EFFECT effectiveness order 0.0 KB HTML
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Mar 29, 2011 S-3ASR automatic shelf registration statement of securities of well-known seasoned issuers 1.9 MB HTML PDF XLS
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Mar 28, 2011 CT ORDER confidential treatment order 10.1 KB HTML PDF
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Mar 17, 2011 8-K current report 76.5 KB HTML PDF XLS
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Mar 16, 2011 10-K annual report 2.0 MB HTML PDF XLS
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Mar 16, 2011 SC 13D/A amended general statement of beneficial ownership 268.6 KB HTML PDF XLS
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Mar 7, 2011 SC 13D/A amended general statement of beneficial ownership 66.0 KB HTML PDF XLS
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Feb 14, 2011 SC 13G/A amended statement of beneficial ownership 34.7 KB HTML PDF XLS
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Feb 14, 2011 SC 13G statement of beneficial ownership 71.6 KB HTML PDF XLS
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Feb 11, 2011 4 van, heek g jan 24.5 KB HTML PDF XLS
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Feb 11, 2011 3/A van heek g jan 21.8 KB HTML PDF XLS
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Feb 7, 2011 CT ORDER confidential treatment order 13.0 KB HTML PDF
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Feb 1, 2011 4 huff, paul 24.9 KB HTML PDF XLS
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Jan 31, 2011 8-K current report 61.8 KB HTML PDF XLS
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Jan 21, 2011 SC 13D/A amended general statement of beneficial ownership 318.1 KB HTML PDF XLS
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Jan 20, 2011 424B3 prospectus filed pursuant to rule 424 25.8 KB HTML PDF XLS
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Jan 11, 2011 8-K/A amended current report 263.1 KB HTML PDF XLS
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Jan 10, 2011 3 rogan manus 26.4 KB HTML PDF XLS
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Jan 6, 2011 424B5 prospectus filed pursuant to rule 424 687.1 KB HTML PDF XLS